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P450 Drug Interaction Table: Abbreviated "Clinically Relevant" Table

SUBSTRATES
1A2	2B6	2C8	2C9	2C19	2D6	2E1	3A4,5,7
clozapine cyclobenzaprine imipramine mexiletine naproxen riluzole tacrine² theophylline²	bupropion¹ cyclophosphamide efavirenz¹ ifosfamide methadone	paclitaxel torsemide amodiaquine² cerivastatin repaglinide	NSAIDs: diclofenac ibuprofen piroxicam Oral Hypoglycemics: tolbutamide glipizide Angiotensin II Blockers: losartan irbesartan Others: celecoxib fluvastatin naproxen phenytoin rosiglitazone sulfamethoxazole tamoxifen tolbutamide torsemide warfarin1	PPIs: lansoprazole omeprazole2 pantoprazole rabeprazole Anti-epileptics: diazepam phenytoin phenobarbitone Others: amitriptyline clomipramine clopidogrel cyclophosphamide progesterone	Beta Blockers: S-metoprolol propafenone timolol Antidepressants: amitriptyline clomipramine desipramine imipramine paroxetine Antipsychotics: haloperidol risperidone thioridazine Others: aripiprazole codeine dextromethorphan1 duloxetine flecainide mexilletine ondansetron tamoxifen tramadol venlafaxine	Anesthetics: enflurane halothane isoflurane methoxyflurane sevoflurane Others: acetaminophen→NAPQI aniline2 benzene chlorzoxazone1 ethanol N,N-dimethyl formamide theophylline→8-OH	Macrolide antibiotics: clarithromycin erythromycin2 (not 3A5) NOT azithromycin telithromycin Anti-arrhythmics: quinidine→3-OH (not 3A5) Benzodiazepines: alprazolam diazepam→3OH midazolam1 triazolam2 Immune Modulators: cyclosporine tacrolimus (FK506) HIV Antivirals: indinavir ritonavir saquinavir Prokinetics: cisapride Antihistamines: astemizole chlorpheniramine Calcium Channel Blockers: amlodipine diltiazem felodipine nifedipine2 nisoldipine nitrendipine verapamil HMG CoA Reductase Inhibitors: atorvastatin lovastatin NOT pravastatin NOT rosuvastatin simvastatin Others: aripiprazole buspirone gleevec haloperidol methadone pimozide quinine sildenafil tamoxifen trazodone vincristine
INHIBITORS
A Strong inhibitor is one that causes a > 5-fold increase in the plasma AUC values or more than 80% decrease in clearance. A Moderate inhibitor is one that causes a > 2-fold increase in the plasma AUC values or 50-80% decrease in clearance. A Weak inhibitor is one that causes a > 1.25-fold but < 2-fold increase in the plasma AUC values or 20-50% decrease in clearance. All other inhibitors.
1A2	2B6	2C8	2C9	2C19	2D6	2E1	3A4,5,7
cimetidine fluoroquinolones fluvoxamine¹ ticlopidine	thiotepa ticlopidine²	gemfibrozil montelukast1	fluconazole2 amiodarone isoniazid	fluoxetine fluvoxamine ketoconazole lansoprazole omeprazole ticlopidine2	bupropion fluoxetine paroxetine quinidine1 duloxetine amiodarone cimetidine chlorpheniramine clomipramine doxepin haloperidol methadone mibefradil ritonavir	disulfiram	HIV Antivirals: indinavir nelfinavir ritonavir clarithromycin itraconazole ketoconazole nefazodone erythromycin grapefruit juice verapamil2 diltiazem cimetidine amiodarone NOT azithromycin fluvoxamine mibefradil troleandomycin
INDUCERS
1A2	2B6	2C8	2C9	2C19	2D6	2E1	3A4,5,7
tobacco	phenobarbital phenytoin rifampin		rifampin secobarbital			ethanol isoniazid	carbamazepine phenobarbital2 phenytoin2 pioglitazone rifabutin rifampin1 St. John's wort troglitazone1
GENETICS
1A2	2B6	2C8	2C9	2C19	2D6	2E1	3A4,5,7
Chr	Chr	Chr	Chr	Chr	Chr 22	Chr	Chr
			Haplotypes: 2=PM 3=PM	Haplotypes: 2=PM (99% in Asians) 3=PM (87% in Whites)	Haplotypes: 2=EM (similar to WT) 3=PM (truncates protein) 4=PM (non-functional) 5=PM (whole gene del.) 6=PM (truncates protein) 9=IM/EM (reduces func.) 10=IM (reduces func.) 17=IM (reduces func.) 29=IM (reduces func.) 41=IM (reduces func.)
Metabolizer Phenotypes: PM = Poor IM = Intermediate EM = Extensive UM = Ultrarapid

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