Lindsey Kennedy, PhD

Bio

Dr. Lindsey Kennedy obtained her PhD in Medical Science in May 2019 from Texas A&M University Health Science Center, and was also awarded the Graduate Award in Research Excellence given to one matriculating PhD student at graduation. Following her PhD training, she joined Indiana University School of Medicine as a post-doctoral fellow in the Department of Gastroenterology and Hepatology. During her post-doctoral training, she was awarded the Autoimmune Liver Disease Pilot Award from the American Association for the Study of Liver Diseases Foundation, as well as a Career Development Award-2 from the VA. She is currently an Assistant Research Professor at Indiana University School of Medicine, and a Health Science Specialist at the Richard L. Roudebush VA Medical Center. Her lab studies the crosstalk between bile duct cells and endothelial cells mediated by angiocrine signaling during cholestatic liver diseases. She also studies the role of estrogen in mediating sexually dimorphic outcomes in cholestatic liver diseases.

Titles & Appointments

Assistant Research Professor of Medicine

Education

2019 PhD Texas A&M University

2013 BS University of Texas
Research
My research interests lie in the cellular crosstalk and pathological mechanisms regulating biliary and liver damage in cholestatic disorders, such as primary sclerosing cholangitis (PSC) and primary biliary cholangitis (PBC). During my training, I have worked on a broad array of studies including fatty liver disease, cholestasis, and liver fibrosis. I have two main projects funded within my lab which focus on the following:
- Estrogen signaling and its dichotomous roles in sex-dependent damage in cholestasis via bile acid signaling and bile flow.
- Endothelin-mediated cholangiocyte-endothelial crosstalk, ductular reaction and pathological angiogenesis during PSC.
Publications

Knockout of secretin ameliorates biliary and liver phenotypes during alcohol-induced hepatotoxicity.
Kyritsi K; Wu N; Zhou T; Carpino G; Baiocchi L; Kennedy L; Chen L; Ceci L; Meyer AA; Barupala N; Franchitto A; Onori P; Ekser B; Gaudio E; Wu C; Marakovits C; Chakraborty S; Francis H; Glaser S; Alpini G; Cell & bioscience 2023 Jan 9

Loss of apical sodium bile acid transporter alters bile acid circulation and reduces biliary damage in cholangitis.
Meadows V; Marakovits C; Ekser B; Kundu D; Zhou T; Kyritsi K; Pham L; Chen L; Kennedy L; Ceci L; Wu N; Carpino G; Zhang W; Isidan A; Meyer A; Owen T; Gaudio E; Onori P; Alpini G; Francis H; 2022 Nov 21

Macrophage-Specific SCAP Promotes Liver and Adipose Tissue Damage in a Lean NAFLD Model: Lean, Mean, Proinflammatory Machine.
Kennedy L; Francis H; Alpini G; Cellular and molecular gastroenterology and hepatology 2022 Apr 29

Looking for patient care?

To schedule an appointment with a faculty member physician of IU School of Medicine, contact Indiana University Health at 888-484-3258 or use the physician finder by clicking the button below.

Find a doctor