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John M. Miller, M.D.
Professor of Medicine

Office:
Methodist Hospital, Room E488
1701 Senate Blvd.
Indianapolis , IN 46202-1239

Phone:  (317) 962-0101
E-mail:  jmiller6@iupui.edu
 
Bio CV Accomplishments

Awards & Honors:

Principal Investigator – Pivotal Clinical Study of the CardioFocus Endoscopic Ablation System (CFEAS) for the Treatment of Symptomatic Atrial Fibrillation (ENABLE) Sponsor: CardioFocus Inc. (2007 [ongoing])

Principal Investigator – Pivotal Clinical Study of the Ablation Frontiers Ablation System for the Treatment of Symptomatic Chronic Atrial Fibrillation Sponsor: Ablation Frontiers Inc. (2007 [ongoing])

Principal Investigator – Atrial Fibrillation Conversion using the Drug RSD 1235 American Board of Internal Medicine – Test Committee for Clinical Cardiac Electrophysiology - Medical Secretary --1990 – 1998 - Member--2002 – 2008 - Chairman--2008 - Sponsor: Fujisawa Healthcare, Inc. (2004 – 2005)

Principal Investigator – Asymptomatic AF and Stroke Evaluation in Pacemaker Patients and the AF Reduction Atrial Pacing Trial (ASSERT) Sponsor: St. Jude Medical, Inc. (2004 [ongoing])

Outstanding Fellows' Teaching Award, Indiana University School of Medicine, Department of Medicine - 1998

Listed in "Who's Who in Medical Sciences Education" - 1999

Principal Investigator Minimal Ventricular Pacing Clinical Download Study Using the Marquis DR Model 7274 Implantable Cardioverter-Defibrillator Sponsor: Medtronic, Inc. (2003 2004)

Charles Fisch Cardiology Fellows' Teaching Award, Indiana University School of Medicine - 2003

Advanced Training Clinical Fellowship Award Sponsor: North American Society of Pacing and Electrophysiology (2001 – 2002)- renewed 2003 (2003 – 2006)

Principal Investigator – Atrial Fibrillation Clopidogrel Trial with Irbesarten for Prevention of Vascular Events (ACTIVE) Sponsor: Sanofi-Synthelab (2003 – 2004)

Principal Investigator – Atrial Flutter Ablation using the CryoCor Catheter Cryoablation System Sponsor: CryoCor, Inc. (2003 – 2004)

Principal Investigator – Atrial Fibrillation Ablation using the CryoCor Catheter Cryoablation System Sponsor: CryoCor, Inc. (2003 – 2004)

Principal Investigator - Chilli Cooled Ablation System for Ventricular Tachycardia Post-Approval Study Sponsor: Boston Scientific Corp. (2003 [ongoing])

Co-Investigator - Worldwide Application Study of Marquis VR Implantable Cardioverter-Defibrillator Enhancements (WAVE) Sponsor: Medtronic, Inc. (2002 present [ongoing])

Charles Fisch Cardiology Fellows' Teaching Award, Indiana University School of Medicine - 2002

Co-Investigator - A Phase 1, Multi-Center, Randomized, Open-Label, Saline-Controlled, Drug Interaction Study Between DTI-0009 and Intravenous Aminophylline (IND # 58,614) Sponsor: Fujisawa Healthcare, Inc. (2002 – 2003)

Co-Investigator - Clinical Investigation of Medtronic Lead Model 3830 Clinical Study Sponsor: Medtronic, Inc. (2002 - 2003)

Co-Investigator - Left Atrial Mapping Protocol (LAMP) Sponsor: Endocardial Solutions, Inc. (2001 - 2002)

Co-Investigator - A Randomized, Open-Label Parallel Group, Dose-Response, Pilot Study of Intravenous DTI-0009 for Ventricular Rate Control in Adult Patients with Atrial Fibrillation (IND # 58,614) Sponsor: Fujisawa Healthcare, Inc. (2001 – 2002)

Co-Investigator - Right Sided Catheter Ablation Study for Left Atrial Isolation Study Sponsor: Medtronic, Inc. (2001 – 2002)

Co-Investigator - Use of Biphasic Defibrillator for Cardioversion of Atrial Fibrillation Sponsor: Zoll Medical Corporation (2000 - 2001)

Co-Investigator - A Double-Blind Comparison of the Incidence of Hypotension with Two Formulation of Intravenous Amiodarone: Cordarone I.V. vs Amiodarone Aqueous I.V. Injection (IND # 39,661) Sponsor: Wyeth-Ayerst Research (2000 - 2001)

Co-Investigator - An Open-Label, Sequential Group, Dose Escalation Electrophysiologic Study of Intravenous DTI-0009 on AV Nodal Function (IND # 58,614) Sponsor: Fujisawa Healthcare, Inc. (2000 - 2001)

Charles Fisch Cardiology Fellows' Teaching Award, Indiana University School of Medicine - 1999

Principal Investigator - Study of Radiofrequency Ablation of Ventricular Tachycardia with Coronary Artery Disease with the Medtronic CardioRhythm Sprinklr Tip Catheter with the Atakr Ablation System (IDE G970123) Sponsor: Medtronic CardioRhythm (1999 - 2000)

Principal Investigator – Study of Radiofrequency Ablation of Ventricular Tachycardia with Coronary Artery Disease with the Medtronic CardioRhythm Sprinklr Tip Catheter with the Atakr Ablation System (IDE G970123) Sponsor: Medtronic CardioRhythm (1999 – 2000)

Co-Investigator - Study of Right Atrial Lesion for Model 7250 for Shock Reduction Sponsor:Medtronic, Inc. (1998 – 1999)

Cardiology Fellows' Teaching Award, Hospital of the University of Pennsylvania - 1998

Co-Investigator - Randomized Study of the ZOLL PD™ 2100 Biphasic External Cardiac Defibrillator for Ventricular tachycardia and Fibrillation. Sponsor: Zoll Medical Corporation (1997 – 1998)

Principal Investigator - Use of the FOCUS 3000™ Mapping System and EnSite™ Catheter in Electrophysiologic Mapping of Right Atrial Endocardium and Guiding Catheter Ablation of Supraventricular Tachycardia (IDE G970142) Sponsor: Endocardial Solutions, Inc. (1997 – 1998)

Principal Investigator - Use of the FOCUS 3000™ Mapping System and EnSite™ Catheter in Electrophysiologic Mapping of Left Ventricular Endocardium and Guiding Catheter Ablation of Ventricular Tachycardia (IDE G960115) Sponsor: Endocardial Solutions, Inc. (1997 – 1998)

Co-Investigator - Atrial Fibrillation Follow-Up Investigation of Rhythm Management (AFFIRM) Sponsor: National Institutes of Health (1996 – present) (Co-Chairman, Death Events Committee)

Co-Investigator - Use of the ATAKR™ Catheter Ablation System in Treatment of Patients with Recurrent Supraventricular Tachycardia. Sponsor: CardioRhythm, Inc. (1994 – 1996)

Co-Investigator - Evaluation of Dofetilide to Prevent Recurrent Ventricular Arrhythmias in Patients with a Cadence Implantable Cardioverter-Defibrillator. Sponsor: Pfizer, Inc. (1993 - 1994)

Co-Investigator - A Randomized, Controlled Trial of Implantable Cardiac Defibrillators Versus Antiarrhythmic Drug Therapy in Survivors of Ventricular Tachycardia or Fibrillation (AVID) Sponsor: National Institutes of Health (1993 – 1997)

Co-Investigator - Randomized Trial of Electrophysiologically Guided Therapy in Patients with Nonsustained Ventricular Tachycardia, Left Ventricular Dysfunction and Coronary Artery Disease (MUSTT) Sponsor: National Institutes of Health, 1 RO1-HL45700 (1992 – 1997)

Principal Investigator - "Interactive Self-Instruction Computer Program in CardiacPacemakers" Sponsor: Philadelphia Health Sciences Libraries Consortium CAI 0190-34, (1990 1991)

Selected Publications:

Vereckei A, Duray G, Szénási G, Altemose GT, Miller JM: A new algorithm using only lead aVR for the differential diagnosis of wide QRS complex tachycardia. Heart Rhythm 5:89-98, 2008.

2. Miller JM (ed) Cardiology Clinics, Volume 26, Number 3, Ventricular Arrhythmias, WB Saunders, Philadelphia, 2008

Vereckei A, Duray G, Szénási G, Altemose GT, Miller JM: Application of a new algorithm in the differential diagnosis of wide QRS complex tachycardia. Eur Heart J 28:589-600, 2007.

Dandamudi G, Ghumman WS, Das MK, Miller JM: Endocardial catheter ablation of ventricular tachycardia in patients with ventricular assist devices. Heart Rhythm 4:1165-1169, 2007.

Miller JM, Bhakta D: The precordial thump: Convertio Cordis, Commotio Cordis, or neither? Pacing and Clin Electrophysiol 30:151-152, 2007.

Miller JM, Zipes DP: Therapy for Cardiac Arrhythmias. In Zipes DP, Libby P, Bonow RO, Braunwald E. (eds) Braunwald’s Heart Disease (8th edition) Elsevier Publishing Co., Philadelphia, pp 779-823, 2007.

Miller JM, Das MK, Yadav AV, Bhakta D: Catheter ablation of superoparaseptal ("anteroseptal") and midseptal accessory pathways. In: Wood MA, Huang SKS (eds), "Catheter Ablation of Cardiac Arrhythmias: Principles and Practical Approach," Saunders Elsevier Publishing Co., Philadelphia, pp 413-425, 2006.

Miller JM, Das MK, Yadav AV, Bhakta D, Nair G, Alberte C: Value of the 12-lead ECG in Wide QRS Tachycardia. In Barold, SS (Ed.) Cardiology Clinics, WB Saunders, Philadelphia, 439-451, 2006.

Miller JM, Das MK: The spectrum of atrial domestication. J Cardiovasc Electrophysiol 17:389-390, 2006.

Miller JM, Pezeshkian NG, Yadav AV: Catheter Ablation of Right Ventricular Outflow Tract Ventricular Tachycardia – Tools and Techniques. J Cardiovasc Electrophysiol 17:800-802, 2006.

Miller JM, Chakka MN, Szwed JM: Post-extrastimulus delay of VT return cycle: An indicator of good ablation site. Heart Rhythm 3:870-871, 2006.

Buxton AE, Calkins H, Callans DJ, DiMarco JP, Fisher JD, Greene HL, Haines DE, Hayes DL, Heidenreich PA, Miller JM, Poppas A, Prystowsky EN, Schoenfeld MH, Zimetbaum PJ. ACC/AHA/HRS 2006 Key data elements and definitions for electrophysiological studies and procedures. A report of the American College of Cardiology/American Heart Association Task Force on Clinical Data Standards (ACC/AHA/HRS Writing committee to Develop Data Standards On Electrophysiology). J Am Coll Cardiol 48:2360-2396, 2006.

Issa Z, Zhou X, Ujhelyi MR, Rosenberger J, Bhakta D, Groh WJ, Miller JM, Zipes DP: Thoracic spinal cord stimulation reduces the risk of ischemic ventricular arrhythmias in a post-infarction heart failure canine model. Circulation 111:3217-3220, 2005.

Issa Z, Ujhelyi MR, Hildebrand KR, Rosenberger BS, Groh WJ, Miller JM, Zipes DP: Intrathecal clonidine reduces the incidence of ischemia-provoked ventricular arrhythmias in a canine post-infarction heart failure model. Heart Rhythm. 2:1122-1127, 2005.

Lindblade CI, Hubbard JE, Miller JM, Batra AS: Anorexia nervosa and ventricular fibrillation. Clin Pediatr 44(9):629-632, 2005.

Issa ZF, Bhakta D, Miller JM: Appropriate or inappropriate ICD therapy? Heart Rhythm 2:1150-1152, 2005.

Issa ZF, Chakka M, Miller JM, Yadav AV: Mechanism of transition from irregular to regular supraventricular tachycardia. Pacing Clin Electrophysiol 28:1107-8, 2005.

Steinberg JS, Sadaniantz A, Kron J, Krahn A, Denny DM, Daubert J, Campbell WB, Havranek E, Murray K, Olshansky B, O’Neil G, Sami M, Schmidt S, Storm R, Zabalgoitia M, Miller JM, Chandler M, Nasco EM, Greene HL and the AFFIRM Investigators: Analysis of cause-specific mortality in the atrial fibrillation Follow-Up Investigation of Rhythm Management (AFFIRM) trial. Circulation 109: 1973-1980, 2004.

Takahashi T, van Dessel P, Lopshire JC, Groh WJ, Miller JM, Wu J, Zipes DP: Optical mapping of the functional reentrant circuit of ventricular tachycardia in acute myocardial infarction. Heart Rhythm 4:452-459, 2004.

Miller JM, Das MK, Arora R, Alberte-Lista C, Wu J: Differential Diagnosis of Wide QRS Complex Tachycardias. In Zipes DP, Jalife J (eds) Cardiac Electrophysiology: from Cell to Bedside (4th Ed.), WB Saunders Co. Philadelphia, pp. 747-757, 2004.

Miller JM, Zipes DP: Diagnosis of Cardiac Arrhythmias. In Zipes DP, Libby P, Bonow RO, Braunwald E. (eds) Braunwald’s Heart Disease (7th edition) Elsevier Publishing Co., Philadelphia, pp. 697-712, 2004.

Miller JM, Zipes DP: Therapy for Cardiac Arrhythmias. In Zipes DP, Libby P, Bonow RO, Braunwald E. (eds) Braunwald’s Heart Disease (7th edition) Elsevier Publishing Co., Philadelphia, pp. 713-757, 2004.

Miller JM, Olgin JE, Das MK. Atrial fibrillation: What are the targets for intervention? J Interventional Card Electrophysiol 9:249-257, 2003.

Miller JM, Olgin JE, Al-Sheikh T, Altemose GT: Surface Electrocardiographic Mapping of Ventricular Tachycardia: Correlation with Electrophysiologic Mapping. In Shenasa M, Borggrefe M, Breithardt G (eds) Cardiac Mapping (2nd Edition) Futura, Elmsford, NY, pp. 455-466, 2003.

Miller JM, Suleman A, Hadian D: Termination of orthodromic supraventricular tachycardia by a non-propagated stimulus. J Cardiovasc Electrophysiol 14 (4):439, 2003.

Navarrete AJ, Arora R, Hubbard JE, Miller JM: Magnetic electroanatomical mapping of an atrial tachycardia requiring ablation within the coronary sinus. J Cardiovasc Electrophysiol 14:1361-1364, 2003.

Guerra JM, Wu J, Miller JM, Groh WJ: Increase in ventricular tachycardia frequency after biventricular implantable cardioverter-defibrillator upgrade. J Cardiovasc Electrophysiol 14:1245-1247, 2003.

Gaitonde RS, Sharma N, Ali-Hasan S, Miller JM, Jayachandran JV, Kalaria VG: Prediction of significant left main coronary artery stenosis by the 12-lead electrocardiogram in patients with rest angina pectoris and the withholding of clopidogrel therapy. Am J Cardiol 92(7):846-848, 2003.

Miller JM, Scott LR: Entrainment of ventricular tachycardia by sinus rhythm. J Cardiovasc Electrophysiol 13:199, 2002.

Hadian D, Zipes DP, Miller JM: Short term rapid atrial pacing produces electrical remodeling of sinus node function in humans. J Cardiovasc Electrophysiol 13:584-586, 2002.

Altemose GT, Zipes DP, Weksler J, Miller JM, Olgin JE: Inhibition of the Na+/H+ exchanger delays the development of rapid pacing induced atrial contractile dysfunction. Circulation 103:762-768, 2001.

Scott LR, Hadian D, Olgin J, Miller JM: Termination of reentrant atrial tachycardia by a non-propagated extrastimulus. J Cardiovasc Electrophysiol 12:388, 2001.

Wu J, Olgin JE, Miller JM, Zipes DP: Mechanisms underlying the reentrant circuit of atrioventricular nodal reentrant tachycardia in isolated canine atrioventricular nodal preparation using optical mapping. Circulation Research 88(11):1189-1195, 2001.

Miller JM, Zipes DP: Management of the patient with cardiac arrhythmia. In Braunwald E, Zipes DP, Libby P. (eds) Heart Disease (6th edition) WB Saunders, Inc., Philadelphia, pp. 700-766, 2000.

Miller JM, Altemose GT, Coppess MA, Mahomed Y: Role of electrophysiologic mapping in ventricular arrhythmia surgery. In Singer I (ed) Interventional Electrophysiology (2nd edition), Lippincott Williams & Wilkins, Philadelphia, pp. 463-479, 2001.

Miller JM, Altemose GT, Jayachandran JV: Catheter ablation of ventricular tachycardia in patients with structural heart disease. Cardiology in Review 9:302-311, 2001

Miller JM, Altemose GT: Wolff-Parkinson-White syndrome, its variants, and concealed bypass tracts. Card Electrophysiol Review 5:315-318, August-September, 2001.

Wu J, Wu J, Olgin JE, Miller JM, Zipes DP: Mechanisms of atrioventricular nodal reentry and ventricular tachycardia determined from optical mapping of isolated perfused preparations. In Zipes DP, Haďssaguerre M (eds) Catheter Ablation of Arrhythmias (2nd edition), Futura Publishing Company, Armonk, NY, (pp. 1-20), 2001.

Miller JM, Olgin JE: Catheter ablation of free-wall accessory pathways including Mahaim fibers. In Zipes DP, Haďssaguerre M (eds) Catheter Ablation of Arrhythmias (2nd edition), Futura Publishing Company, Armonk, NY, (pp. 249-276), 2001.

Darbar D, Olgin JE, Miller JM, Friedmann PA: Localization of the origin of arrhythmias for ablation: from ECG to advanced endocardial mapping systems. J Cardiovasc Electrophysiol 12: 1309-1325, 2001.

Miller JM, Rothman SA, Hsia HH, Vogel RL, Buxton AE. Ablation of Mahaim fibers. In Huang S, Wilber D (eds). Radiofrequency Catheter Ablation of Cardiac Arrhythmias: Basic Concepts and Clinical Applications, Futura, Armonk, New York, pp. 559-578, 2000.

1. Miller JM (ed) Cardiology Clinics, Volume. 18, Number 2, Ventricular Arrhythmias, WB Saunders, Philadelphia, 2000.

Altemose GT, Miller JM: Termination of ventricular tachycardia by a non-propagated extrastimulus. J Cardiovasc Electrophysiol 11:125, 2000.

Altemose GT, Scott LR, Miller JM: Identical atrial activation during spontaneous initiations of atrial fibrillation. J Cardiovasc Electrophysiol 11:373, 2000.

Sehra R, Coppess MA, Altemose GT, Militello CA, Miller JM: Atrial tachycardia masquerading as atrial flutter following ablation of the subeustachian isthmus. J Cardiovasc Electrophysiol 11:582-586, 2000.

Coppess MA, Miller JM, Zipes DP, Altemose GT, Jayachandran JV, Al-Sheikh T: Unusual features of intermediate septal bypass tracts. J Cardiovasc Electrophysiol 11:730-735, 2000.

Altemose GT, Scott LR, Miller JM: Atrioventricular nodal reentrant tachycardia requiring ablation on the mitral annulus. J Cardiovasc Electrophysiol 11(11):1281-1284, 2000.